Fri Jul 29 2022

74 articles - From Friday Jul 22 2022 to Friday Jul 29 2022

parm_toc.knit

Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Clin Kidney J

Use of erythropoiesis-stimulating agents in children with chronic kidney disease: a systematic review.

All ESA preparations and modes of administration were efficacious, with evidence of harm at higher doses. Evidence supports individualizing treatments, with strong consideration given to alternate treatments in patients who appear resistant to ESA therapy. Further research should focus on randomized trials comparing the efficacy of different preparations, treatment options in apparently ESA-resistant cohorts and clarification of meaningful secondary outcomes to consolidate patient-relevant indices.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Kidney Dis

Australian Rural Caregivers' Experiences in Supporting Patients With Kidney Failure to Access Dialysis and Kidney Transplantation: A Qualitative Study.

Australian rural caregivers of people with kidney failure treated by maintenance dialysis or transplantation experience an exhausting physical, financial, and psychological burden. Strategies to address these profound challenges are needed.

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Patient and Clinician Perspectives on Shared Decision Making in Vascular Access Selection: A Qualitative Study.

Findings suggest that earlier, or upstream, decisions about kidney replacement therapies influence how and when VA decisions are made. Repeated VA discussions that are integrated with other higher-level decisions are needed to promote VA shared decision-making and preparedness.

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Prediction of Mortality and Major Adverse Kidney Events in Critically Ill Patients With Acute Kidney Injury.

The reported clinical models exhibited better performance for mortality and kidney recovery prediction compared to standard scoring tools commonly used in critically ill patients with AKI in the ICU. Additional validation is needed to support the utility and implementation of these models.

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Clin J Am Soc Nephrol

Automated Prediction of Kidney Failure in IgA Nephropathy with Deep Learning from Biopsy Images.

The deep learning approach was noninferior to manual histopathologic reporting and considered prognostic features not currently included in MEST-C assessment. Podcast This article contains a podcast at

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Implications of Accumulated Cold Time for US Kidney Transplantation Offer Acceptance.

The acceptability of marginal organs rises when placements are nearer to the donor and when cold ischemia time is reduced.

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Long-Term Effect of Physical Exercise on the Risk for Hospitalization and Death in Dialysis Patients: A Post-Trial Long-Term Observational Study.

A simple, personalized, home-based, low-intensity exercise program was associated with a lower risk of hospitalization. Clinical trial registry name and registration number EXerCise Introduction to Enhance Performance in Dialysis (EXCITE), NCT01255969.

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Patterns in Tacrolimus Variability and Association with De Novo Donor-Specific Antibody Formation in Pediatric Kidney Transplant Recipients.

Background and objectives High tacrolimus intrapatient variability has been associated with inferior graft outcomes in patients with kidney transplants. We studied baseline patterns of tacrolimus intrapatient variability in pediatric patients with kidney transplants and examined these patterns in relation to C1q-binding donor-specific antibody formation.

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Short- and Long-Term Progression of Kidney Involvement in Systemic Lupus Erythematosus Patients with Low-Grade Proteinuria.

0.5 g/g in a short time period supporting the role of early biopsy to diagnose and treat lupus nephritis.

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Short-Term Changes in Serum Potassium and the Risk of Subsequent Vascular Events and Mortality: Results from a Randomized Controlled Trial of ACE Inhibitors.

Continuation of angiotensin-converting enzyme inhibitor-based therapy consistently decreased the subsequent risk of clinical outcomes, including cardiovascular and kidney outcomes and death, regardless of short-term changes in serum potassium. Clinical trial registry name and registration number Action in Diabetes and Vascular Disease Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE), NCT00145925.

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Clin Kidney J

Baseline characteristics and evolution of Brazilian patients with atypical hemolytic uremic syndrome: first report of the Brazilian aHUS Registry.

Renal involvement was observed in al cases and 37% had low C3 levels. In the deletion with no preference of age, a peculiar pattern of Brazilian patients.

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Chronic kidney disease, survival and graft-versus-host-disease-free/relapse-free survival in recipients of allogeneic hematopoietic stem cell transplant.

CKD adversely affects the long-term prognosis for allogeneic HSCT recipients, with increased mortality risk and worse GVHD-free/relapse-free survival.

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DLEU7-AS1 promotes renal cell cancer by silencing the miR-26a-5p/coronin-3 axis.

Interestingly, exogenous expression of coronin-3 or miR-26a-5p inhibitor treatment almost completely rescued the DLEU7-AS1 knockdown-induced inhibitory effects on cell proliferation, migration and invasion. In conclusion, our data demonstrate that DLEU7-AS1 is an oncogene in RCC capable of regulating the growth and metastasis of RCC by silencing the miR-26a-5p/coronin-3 axis, suggesting that DLEU7-AS1 can be employed as a potential therapeutic target and prognostic biomarker for RCC.

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Dynamics of SARS-CoV-2-Spike-reactive antibody and T-cell responses in chronic kidney disease patients within 3 months after COVID-19 full vaccination.

Most HD, PD and ACKD patients develop SARS-CoV-2-S antibody responses comparable to that of healthy controls, in contrast to KT recipients. Antibody waning at 3M was faster in HD, PD and ACKD patients. No differences in SARS-CoV-2 T-cell immunity responses were noticed across study groups.

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Evaluation of the impact of an intradialytic exercise programme on sarcopaenia in very elderly haemodialysis patients.

In conclusion, EWGSOP2 steps remain stable in stable very elderly persons on HD and STS-5 is responsive to a short-term intradialytic lower limb exercise programme. These results may help define EWGSOP2-based primary endpoints in future large-scale clinical trials assessing exercise interventions.

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Half a century of haemodialysis: two patient journeys.

This report describes two patients who commenced dialysis at the age of 17 and 27, for 53 and 45 years, respectively, whereby the modality of RRT was mostly in the form of home haemodialysis. The history of these two patients, who started RRT in distant parts of the world, Australia and Croatia, highlights not only the advances made over time, to significantly delay the onset and reduce the morbidity and mortality associated with ESKD, but also underlines the importance of empowerment and commitment, added values in home haemodialysis.

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Kidney function and the risk of sudden cardiac death in the general population.

Reduced kidney function is associated with increased SCD risk in the general population, especially with eGFRcys. eGFRcys could be added to prediction models and screening programmes for SCD prevention.

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Semaglutide in type 2 diabetes with chronic kidney disease at high risk progression-real-world clinical practice.

The main objectives were glycemic control as HbA1c 50% in patients with macroalbuminuria. The administration of GLP-1RA in patients with T2D and CKD was safe and well tolerated.

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Soluble urokinase plasminogen activator receptor and decline in kidney function among patients without kidney disease.

A higher suPAR level was associated with accelerated eGFR decline among patients presenting to the emergency department, suggesting that routine suPAR measurements may have utility for the early detection of kidney disease.

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Kidney Int

A randomized controlled pilot trial of anakinra for hemodialysis inflammation.

Thus, anakinra was well tolerated and did not increase infections or cytopenias. The promising safety data and potential efficacy on CRP and IL-6 provide support for conducting definitive trials of IL-1 inhibition to improve outcomes in hemodialysis patients.

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Antigen-specific B cells in kidney transplantation.

Importantly, they demonstrate that these antigen-specific B cells are found at a greater frequency in sensitized kidney transplant recipients when compared with healthy volunteers. Finally, using an indirect antigen-specific enzyme-linked immunosorbent spot assay, they uncover the complexity of B- and T-cell interactions and the influence of regulatory T cells on such interactions in vitro.

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Heparin, klotho, and FGF23: the 3-beat waltz of the discordant heart.

In this issue, Yanucil et al investigated the interaction of soluble klotho and heparin with FGF23 and FGF receptor isoforms. They concluded that heparin promotes the FGF23-FGF receptor isoform 4 interaction and FGF23 pathogenic effects, supporting an important role of heparin in the pathogenesis of FGF23-mediated left ventricular hypertrophy in chronic kidney disease.

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Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.

Many trans- pQTLs were found to reflect associations mediated by the circulating cis protein, and the common trans-pQTLs are enriched for processes involving extracellular vesicles, highlighting a plausible mechanism for distal regulation of the levels of secreted proteins. Thus, our study generates a valuable resource of genetic associations linking variants to protein levels and disease in an understudied patient population to inform future studies of drug targets and physiology.

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Multiple molecular mechanisms are involved in the activation of the kidney sodium-chloride cotransporter by hypokalemia.

Similarly, phospho-KLHL3 was modulated by changes in intracellular chloride in HEK293 cells. Thus, our data suggests that multiple chloride-regulated mechanisms are responsible for NCC upregulation by low extracellular potassium.

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Novel gold-platinum nanoparticles serve as broad-spectrum antioxidants for attenuating ischemia reperfusion injury of the kidney.

Meanwhile, AuPt NPs also had an effect on inhibiting the transition to chronic kidney disease by reducing kidney fibrosis in the long term. Thus, AuPt NPs might be a good therapeutic agent for kidney IRI management and may be helpful for the development of clinical treatments for kidney IRI.

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Proteomic discovery in diabetic kidney disease-to what end?

Kobayashi et al provide a valuable addition to this literature, describing an untargeted proteomic analysis of diabetic kidney disease progression to end-stage kidney disease. This commentary places the study's findings in the context of the broader literature and outlines potential avenues toward biological insight and clinical utility.

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Recognizing the true face of noninfectious cryoglobulinemic glomerulonephritis.

The complexities of different types and changing etiologies of cryoglobulinemias determine its heterogeneous clinical manifestations and diagnostic difficulties. In this issue of Kidney International, Javaugue et al have emphasized the diagnostic points of cryoglobulinemic glomerulonephritis and hematological disorders as the major culprits of noninfectious cryoglobulinemic glomerulonephritis in a large cohort.

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The fate of erythropoietin-producing cells: another piece of the puzzle.

The authors show that Epo-producing cells become proliferating, profibrotic cells after kidney injury and lose their ability to produce Epo. Furthermore, they show that the fluorescent-labeled cells can recover their Epo synthesis capability subsequently to a recovery period.

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Nephrol Dial Transplant

AA Amyloidosis associated with cancers.

The mainstay of treatment consists of therapy directed against the underlying malignancy or careful withdrawal of the offending agent. This review will discuss this rare but highly morbid clinical condition.

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Care processes and outcomes of deprivation across the clinical course of kidney disease: findings from a high-income country with universal healthcare.

Even in a high-income country with universal healthcare, serious and consistent inequities of kidney care exist. The poorer care and outcomes with area-level deprivation were greater earlier in the disease course.

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Comparison of measured vs. kinetic-model predicted phosphate removal during hemodialysis and hemodiafiltration.

Addition of EUDIAL-recommended convective clearance equations to a phosphate kinetic model predicts a 10% or greater benefit in terms of phosphate removal for HDF compared to HD at typical dialysis and hemodiafiltration treatment settings. These predictions are similar to the HDF advantage reported in the literature in studies where phosphate removal has been measured in spent dialysate.

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Patient views regarding cannabis use in chronic kidney disease and kidney failure: a survey study.

Many patients with kidney disease use cannabis and there is interest in trying cannabis for symptom control.

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Renal sarcoidosis.

Although RS usually responds well to corticosteroids, the disease may have a chronic course and require long-term immunosuppressive therapy. The risk of progression to ESRD is rare.

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Serum phosphate as an independent factor associated with cholesterol metabolism in patients undergoing hemodialysis: a cross-sectional analysis of the DREAM cohort.

An independent association was found between phosphate and campesterol levels in patients with kidney failure. This study suggests a novel relationship between phosphate and cholesterol metabolism, both of which could affect cardiovascular outcomes in this population.

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The Direct Effect of Fibroblast Growth Factor 23 on Vascular Smooth Muscle Cells Phenotype and Function.

In VSMC, high levels of FGF23, through the downregulation of miR-221/222, causes a change to a synthetic phenotype. This change in VSMC increases arterial stiffening and impairs vascular function which might ultimately worsens cardiovascular disease.

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The kidney reabsorption-related Magnesium Depletion Score is associated with increased likelihood of abdominal aortic calcification among US adults.

The MDS is a promising tool for identifying individuals with magnesium deficiency status who may benefit from dietary magnesium supplementation to reduce the risks of AAC.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Kidney Dis

Exercise and Kidney Disease Prevention: Walk This Way.

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Performance of New Estimated GFR Equations in Kidney Transplant Recipients: A Step in the Right Direction.

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The Whole Picture.

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Three Pounds and Seven Ounces: My Patient Activation Journey.

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Water In and Water Out-Or Just the Opposite? The Need to Understand Our Patients' Illnesses in Their Own Words.

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Clin J Am Soc Nephrol

Calamari, Hyperkalemia, and Renin-Angiotensin System Blockade.

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Pathophysiological Implications of Variability in Blood Tacrolimus Levels in Pediatric and Adolescent Kidney Transplant Recipients.

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Clin Kidney J

A roadmap to parathyroidectomy for kidney transplant candidates.

Ideally parathyroidectomy should be performed before kidney transplantation to prevent persistent hyperparathyroidism and improve graft outcomes. We now propose a roadmap for the management of secondary hyperparathyroidism in patients eligible for kidney transplantation that includes the indications and timing (pre- or post-kidney transplantation) of parathyroidectomy, the evaluation of parathyroid gland size and the integration of parathyroid gland size in the decision-making process by a multidisciplinary team of nephrologists, radiologists and surgeons.

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Anaplastic lymphoma kinase inhibitors and their effect on the kidney.

According to the package insert and published literature, treatment with several ALK-1 inhibitors appears to be associated with the development of peripheral edema and rare electrolyte disorders, kidney failure, proteinuria and an increased risk for the development and progression of renal cysts. This review introduces the different types of ALK inhibitors, focusing on their detailed kidney-related side effects in clinical practice.

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Visit-to-visit blood pressure variability and risk of dementia in chronic kidney disease patients: why are blood pressure changes so important in cognitive functions?

Both higher systolic and diastolic BP variabilities were associated with any type of dementia, including Alzheimer's and vascular dementia. Physicians must be aware of BP variability when evaluating CKD patients with hypertension.

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Wasp stings and plasma exchange.

The WSS will require external validation. This manuscript should raise awareness about the potentially fatal consequences of stings by wasp species making their way into America and Europe.

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Kidney Int

The impact of dietary nutrient intake on gut microbiota in the progression and complications of chronic kidney disease.

In this review, we describe the latest advances in understanding diet-microbiota crosstalk in a uremic context, and how this communication might contribute to CKD progression and complications. We then discuss how this knowledge could be harnessed for personalized nutrition strategies to prevent patients with CKD progressing to end-stage kidney disease and its detrimental consequences.

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The kidney matrisome in health, aging and disease.

Coupled with single cell transcriptomics there is the potential to identify the cellular origin of matrix changes, which could enable cell targeted therapy. This review provides a contemporary perspective of the complex kidney matrisome and draws comparison to altered matrix in heart and liver disease.

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Nat Rev Nephrol

Principles of human and mouse nephron development.

Greater insights into the complex cellular movements that occur as the proximal-distal axis is established have challenged our understanding of nephron patterning and provided important clues to the elaborate developmental context in which human kidney diseases can arise. Studies of kidney development in vivo have also facilitated efforts to recapitulate nephrogenesis in kidney organoids in vitro, by providing a detailed blueprint of signalling events, cell movements and patterning mechanisms that are required for the formation of correctly patterned nephrons and maturation of physiologically functional apparatus that are responsible for maintaining human health.

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Letters&Replies

Letters to the editors and authors’ replies

Kidney Int

Covid-19 morbidity decreases with Tixagevimab/cilgavimab preexposure prophylaxis in kidney transplant recipients non/low vaccine responders.

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Do the benefits of subcutaneous immunoglobulin therapy for secondary hypogammaglobulinemia in ANCA vasculitis extend beyond infection prevention?

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The appearance of oxalate crystals in a kidney biopsy is no proof of post-transplant oxalate nephropathy in primary hyperoxaluria type 1.

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The art and science of the possible in glomerular filtration rate measurement.

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The authors reply.

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Others

all remaining publications eg case reports, images of the month, etc…

Am J Kidney Dis

Sudden Gross Hematuria in a Hemodialysis Patient.

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Clin J Am Soc Nephrol

Correction: CRRT Fluid Choices: A Solution for a Common Problem?

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Correction: Fractional Excretion of Sodium (FENa): An Imperfect Tool for a Flawed Question.

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Clin Kidney J

Cardiovascular risk assessment in lupus nephritis and ANCA-associated vasculitis in real-world nephrology practice.

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Depression and clinical outcomes in CKD: do anti-depressants play a role? (EQUAL study).

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Humoral response after SARS-CoV-2 booster vaccination in haemodialysis patients with and without prior infection.

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Reply to 'Depression and clinical outcomes in CKD: do anti-depressants play a role? (EQUAL Study)'.

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Risk factors of venous thromboembolism in anti-PLA2R-positive and negative primary membranous nephropathy.

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Kidney Int

A farmer's child with kidney failure.

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Acute kidney injury and "clogged chimneys".

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Bilateral renal lymphangiectasia.

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The Case | A pregnant female with refractory hypocalcemia.

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What to do when a child with nephrotic syndrome has a cold? Learning from RCTs.

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Nat Rev Nephrol

Determining treatment response in lupus nephritis.

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Quantifying access to transplantation.

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Stem cell-kidney transplantation in Schimke immuno-osseous dysplasia.

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Unmet care needs of minority groups on dialysis.

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UTX regulates accumulation of lipids via kidney serine.

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Nephrol Dial Transplant

TESTING the effects of corticosteroids in patients with IgA nephropathy.

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